Cristyler.com

Itanium? Solutions Alliance today announced the second annual Itanium Solutions Alliance Innovation Award. This year's winners are: the University of Houston bioinformatics research team was "Human Innovation Award"; Protégésoft was "Enterprise Business Application Award"; S7 Software was "Entrepreneurial Innovation Award." This global awards program that recognizes those who through Intel ? Itanium? Processor technology to solve complex humanitarian, business and entrepreneurship, innovation challenges and achievements. Winners each receive a sum of 50,000 U.S. dollars in cash rewards, but also their choice to donate money to a charity. Itanium Solutions Alliance executive director JoanJacobs said: "The winners and finalists solution clearly shows the Itanium? Solution relative to the higher cost of a mainframe, in practical application has significant value. They The story clearly shows that Intel Itanium technology applications for solving problems of mission critical computing environments play a significant role. Participants broad categories, which were selected from each category a winner far from easy. Itanium 3 Solutions Alliance would like to extend my warm congratulations to the winners! " Human contribution to the Innovation Award winners, the University of Houston researchers Dr. Yuriy Fofanov Dr. LennartJohnsson and his research team developed an application using high-performance computing solutions and the latest genome sequencing technology to identify and monitor the microbial gene diversity. The group's mission is to study global warming, human activity and toxic waste, in order to protect humans and other organisms and the environment against the harmful greenhouse gases, and Itanium systems was that they needed to advance the calculation of power tools. Bioinformatics Laboratory of the University of Houston Dr. Fofanov director, said: "Intel's Itanium processor, a powerful high-performance computing capabilities will enable scientists to enhance understanding of the micro-organisms, which is an indispensable factor in our study, important because we need to analyze genetic information. With Itanium systems Memory Bandwidth, we can operate the necessary genetic information, special data structure stored. In addition, the Itanium system, high availability to help us launch a new research project to promote the human environment, public health and safety, sustainable energy and other research advances. " "Enterprise Business Application" award winners to use the Intel Itanium architecture Protégésoft company replaced the original customer outdated and cumbersome system to give full play to the availability of powerful Itanium systems. Protégésoft developed FinancialPortfolioBuilder (FPB), a run on four-way Intel Itanium processor HP Integrity Server The comprehensive financial investment system. FPB supports a variety of portfolio management functions, including account settings, account maintenance, investment in distribution, monitoring and dynamic re-calculation, reporting and so on, all functions in one unified platform. For financial institutions, FPB can be re-counted within minutes thousands of customer accounts, not only can optimize risk and return risk, but also lower cost, higher performance to provide even better customer service. Using the tool, the investment banking clients access to more than 22% compound annual returns on investment, enhance efficiency than traditional methods nearly 3 million times. Protégésoft KumaranPillai CEO, said: "Itanium chip and platform with outstanding reliability and powerful features, its capacity to meet our requirements, giving us great help. Itanium flexible and scalable architecture improve the return on investment, so investment banks can be processed within minutes thousands of customer accounts. " S7 Software Solutions Company with a line of 200 million Software Code ported to Intel Itanium architecture unique projects to receive "Entrepreneurial Innovation" award. The project target is a "Fortune" hundred companies to support financial institutions processing, mortgage loan processing and other services, products, trading systems. With a shorter response time, higher availability and flexible scalability, Itanium platform, the solution to the migration problem of the ideal choice. S7 Software Solutions PhanirajRaghavendra software architect, said: "By the application engine customers to migrate to Intel Itanium architecture, we help our clients fully exploit the Itanium system scalability and performance advantages, including shorter trading hours, security, 24-hour processing and a wide range of software environments. Innovation Award this year by a panel of 11 industry experts. You judge according to level of difficulty, achieved results and to assess candidates for originality. Candidates can only apply for one of three groups and asked demonstrate the following criteria: "Application" of human innovation and contribution to the "award must demonstrate through scientific research, social improvements or other humanitarian work effectively demonstrated its profound impact on humans; "Application" Enterprise Business Application "award must prove hard business results, such as reducing costs and improving return on investment, or soft business impact, including customer satisfaction and new product development; "" Entrepreneurial Innovation "Award, for the last fiscal year the total income of less than 25 million U.S. dollars of private enterprise, designed to reward those who through IT consolidation, increased ROI, increased customer satisfaction and new product development areas of deployment of Itanium systems and innovative applications to achieve tangible results.

About the Author

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NRDC's 2012 Growing Green Award Winners' Film

Yankees Starting

Sun, 20 May 2012 11:35:43 +0000

Yankees Starting

Starting Lineup Baseball Action Figure Steve Sax New York Yankees 1990 NEW
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Recognizing American Patriotic Music through "Yankee Doodle" & "America the Beautiful" by Miguel Carlos

Patriotic music encourages feelings of national unity. They can come in the form of national songs, hymns and even military themes. Below are two examples of popular patriotic songs in the US.

"Yankee Doodle"

Who among us have not heard of this song? It s not only a popular children's song, it is also one of America's patriotic songs. As a matter of fact, it is the state song of Connecticut.

The problem with the song is that despite its popularity, there are those who scrutinize it for the way it made fun of American troops. Thus, this song still became a part of American patriotism.

We can trace the origin of this song to old English folk music. It emerged prior to the American Revolution. It is how the British mocked American soldiers. This is how the term "yankee" came about as a negative term for the Americans. For "doodle", the term implies "simpleton" or "fool".

With regards to its inclusion in the American Revolution, when the Americans or "Yankees" began taking the British into the Revolution, they were also able to take command over this song. They started singing it proudly as a way to taunt English soldiers.

"America the Beautiful"

This is an American folk song that is often referred to as the national hymn of the US. This piece was adapted from Katharine Lee Bates, a Wellsely College English professor. She wrote in the year 1893 during her trip to Colorado. It mentions the beauty of the country she is traveling to. According to her, she got her inspiration from her visit to Pike's Peak.

The original version of this piece, only had four verses. After a while, they expanded it to eight verses and revised the lyrics. It was used by The Congregationalist to commemorate Independence Day in the year 1895. It was Samuel Ward, a New Jersey composer who gave music to the poem. A combination of both the poem and the music was first heard in 1910.

Though there was talk that "America the Beautiful" may replace "The Star Spangled Banner", there's no indication that this would even happen - nor if it is even considered. Still, the song projects the physical beauty and breadth of the United States.

About the Author

There are more examples of American http://www.patrioticmusic.org>">patriotic music and other patriotic songs from other countries at PatrioticMusic.Org.
New York Yankees Starting Lineup 5-12-12

Doubles Slu

Sat, 19 May 2012 08:40:01 +0000

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Spinning Reels of the Modern Fishing Tackle Industry by Vien Menguy

The Mitchell Blade ALU 4500 Spinning reel is one of the newest additions of to the innovative yet simple fishing tackle industry today. This rod considers its high performance corrosion resistant (HPCR) ball bearings as its most important design. Rugged aluminum is the material used to create the body and rotor design of this rod and reel system. This model is considered as one of those with the best designs in the industry at present because of these features.

As already mentioned, one of the greatest innovations of this reel and rod system is its reel's ball bearings which are high performance corrosion resistant. The five ball bearings including the extra one is created and not merely coated with HPCR material so this reel can survive high pressure. Another plus factor is the reel's ability to run in dry and wet conditions without any loss in performance or efficiency. The bearings of this fishing tackle, moreover, are very low maintenance and saltwater resistant so it is truly the perfect tool for hardcore anglers.

The spool utilized on the spinning reel of this fishing tackle is double anodized. Anodization can be described as an electrochemical process of strengthening and hardening aluminum twice in order for the material in the fishing equipment to have high tensile strength and efficiency during stressful conditions. The power knob which is used to control the reel can be bought in sizes sixty and fifty and it also has an extra aluminum spool.

Strength is not the only glowing feature of this fishing tackle. The retrieve system of this spinning reel can both be used for left and right hand. There is also an anti-twist titanium line roller and a machined aluminum handle which provides precision as well as reliability during performance. Titanium is a special material that is only commonly used on high performance machines like Formula One cars and aircrafts for example. Therefore, users can expect this model to perform well even during difficult situations because this metal is integrated on its rod. Saltwater conditions are also properly handled by this model because of the stability that its anti-reverse system offers.

The design of this fishing tackle reel is built out of rust free aluminum. Despite its heavy duty capabilities, it only weighs in at a meager 373 grams. It has one of the highest retrieve ratio (6.2:1) among the rods on its same class and it can also carry 300 meters of 0.25 test line with ease. Moreover, often overlooked on this fishing tackle is its effective front drag system which offers the users smooth and slow pulling of the line without experiencing any jerky movements.

The Mitchell fishing tackle line was first created in France during the 1940s but shortly became one of the leading brands of the fishing magnate Pure Fishing. At present, the brand is considered equal to other brands like Fenwick, Berkley, and Abu Garcia. Ever since it was created, the brand has successfully continue its legacy of providing top quality products to various levels of anglers specifically to those who want to improve their rod's spinning technology. Blade SLU 450 is truly a model that you will never go wrong with.

About the Author

I have been fishing since i was 9 years old and absolutely nothing relaxes me more. To get the best money saving deals on fishing tackle throughout the uk i recommend KeensTackleandguns. Their friendly staff are extremely knowledgeable on everything relevant to fishing and are always very helpful. Take a look at their online fishing tackle store for more details or call 01656 722448.
SLU Shannon Murphy/Elizabeth Geer vs. Nazareth

Deion Sanders

Sat, 19 May 2012 07:59:56 +0000

Deion Sanders

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Atlanta Falcons by Jessydsouza

With three straight winning seasons and a pair of playoff appearances since 2008, the Atlanta Falcons are building a special force heading into the 2011 campaign. Atlanta Falcons tickets are moving quickly, as a winning culture is being established for the franchise.

Atlanta Falcons Tickets: Franchise History

In 1966, the Atlanta Falcons became the first NFL franchise to be based in the southeast. As an expansion team, it took time for the Falcons to build a competitive team. Atlanta reached the postseason for the first time in 1978.

During the sixties and seventies, linebacker Tommy Nobis, defensive lineman Claude Humphrey, center Jeff Van Note and quarterback Steve Bartkowski were among the star players for the Falcons.

In 1980, Atlanta won its first division title with a 12-4 record. In the eighties and early nineties, running back Gerald Riggs and defensive back Deion Sanders were Atlanta's top performers.

After playing at Atlanta's Fulton-County Stadium from 1966-91, the Falcons moved into its current home, which is the Georgia Dome, in 1992.

Atlanta's Super Bowl Season

The 1998 season marked the highpoint for the franchise. Following an outstanding 14-2 regular season, the Falcons reached the NFC Championship Game. Against the 15-1 Minnesota Vikings, Atlanta won a dramatic 30-27 overtime decision to reach Super Bowl XXXIII.
While the Falcons came up short in a 34-19 setback against the Denver Broncos, Atlanta's first NFC title brought plenty of excitement to the city. Running back Jamal Anderson and quarterback Chris Chandler were two of the team's outstanding players in 1998.

Atlanta Falcons Tickets at the Georgia Dome

The Georgia Dome (capacity of 71,228) enables Falcons fans to enjoy all of the NFL action in a comfortable environment. The stadium has hosted two Super Bowls and a pair of NCAA Basketball Final Fours. With a capacity of over 70,000, there are plenty of seating options to explore when purchasing Atlanta Falcons tickets.

Current Stars on the 2011 Home Slate

Behind quarterback Matt Ryan, running back Michael Turner, wide receiver Roddy White and defensive end John Abraham, the Atlanta Falcons are poised to be a title contender again in 2011. This year, the New Orleans Saints, Green Bay Packers and Philadelphia Eagles will take on the Falcons in marquee affairs at the Georgia Dome. Atlanta Falcons tickets will also be available for home games against the Tampa Bay Buccaneers, Carolina Panthers, Minnesota Vikings, Jacksonville Jaguars and Tennessee Titans. Under successful head coach Mike Smith, the Falcons will be poised to give the fans some more good times.

About the Author

GoodSeatTickets.com is a premier source for Atlanta Falcons tickets. Through our dedication to providing stellar customer service and rock-bottom discount ticket pricing, we have enjoyed tremendous success and customer satisfaction
Deion Sanders Tribute - Primetime | HD

Stadium Stars

Sat, 19 May 2012 07:40:07 +0000

Stadium Stars

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1994 KENNER STARTING LINEUP STADIUM STAR BO JACKSON WHITE SOX VERY RARE
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Hank Aaron Stadium Stars Cooperstown Collection 1997 NIB Atlanta Fulton Stadium
US $3.00

NY Yankees Mickey Mantle Starting Lineup and Sports Illustrated
US $24.99

STARTING LINEUP GRIDIRON GREATS SAN FRANCISCO 49ERS SLU JOE MONTANA
US $12.99

SHAQ ONEAL WAYNE GRETZKY RC STARTING LINEUPS LK
US $24.95

Starting Lineup Stadium Stars 6 Different Ripken Griffey Jr Clemens
US $15.95

2 BOSTON RED SOX From Yester Year Stadium Stars ROGER CLEMENS MO VAUGHN
US $7.99

Starting lineup stadium stars Mark McGuire 1999
US $30.00

1997 COOPERSTOWN COLLECTION HANK AARON ACTION FIGURE
US $9.99

1994 KIRBY PUCKETT STARTING LINEUP STADIUM STARS METRODOME MINT
US $9.99

1994 JUAN GONZALEZ STARTING LINEUP STADIUM STARS TEXAS STADIUM MINT
US $9.99

1992 ROGER CLEMENS STARTING LINEUP STADIUM STARS FENWAY PARK MINT
US $9.99

1992 NOLAN RYAN STARTING LINEUP STADIUM STARS ARLINGTON STADIUM MINT
US $9.99

1994 REGGIE JACKSON STARTING LINEUP STADIUM STARS OAKLAND COLISEUM MINT
US $9.99

1995 KEN GRIFFEY JR STARTING LINEUP STADIUM STARS THE KINGDOME MINT
US $9.99

1999 ALEX RODRIQUEZ STARTING LINEUP STADIUM STARS MINT
US $9.99

1998 CAL RIPKEN JR STARTING LINEUP STADIUM STARS MINT
US $9.99

1996 CAL RIPKEN JR STARTING LINEUP STADIUM STARS ALL STAR GAME MINT
US $9.99

1996 MIKE PIAZZA STARTING LINEUP STADIUM STARS ALL STAR GAME MINT
US $9.99

1992 FRANK THOMAS Stadium Stars STARTING LINEUP Comiskey Park 1992 WHITE SOX
US $6.70

NY Yankees 5 open action figures HOF All star andy pettitte collector pin
US $38.49

Stadium Stars Cooperstown Collection Mickey Mantle Mint In Box
US $12.99

Stadium Stars Cooperstown Collection Babe Ruth Mint In Box
US $12.99

STARTING LINEUP CAL RIPKEN JR STADIUM STARS 1998
US $14.99

ROBIN VENTURA STADIUM STARS 1996 WITHOUT BOX VG
US $2.99

CAL RIPKIN JR 96 ALL STAR GAME STADIUM STARS COLLECTIBLES VETERANS STADIUM NEW
US $4.00

1997 Starting Lineup Mike Schmidt Figurine
US $8.95

STARTING LINEUP MLB 1999 STADIUM STARS MARK McGWIRE CARDINALS OPEN LOOSE
US $1.95

STARTING LINEUP MLB 1998 STADIUM STARS ALBERT BELLE WHITE SOX OPEN LOOSE VHTF
US $1.95

STARTING LINEUP MLB 1998 STADIUM STARS JOHN SMOLTZ BRAVES OPEN LOOSE VHTF
US $1.95

STARTING LINEUP MLB STADIUM STARS 1999 MARK McGWIRE CARDINALS VHTF
US $2.95

STARTING LINEUP MLB 2000 ELITE STADIUM STARS SAMMY SOSA CUBS OPEN LOOSE VHTF
US $1.95

STARTING LINEUP MLB 2000 ELITE STADIUM STARS MARK McGWIRE CARDINALS OPEN LOOSE
US $1.95

STARTING LINEUP MLB 2000 ELITE STADIUM STARS GREG MADDUX BRAVES OPEN LOOSE VHTF
US $1.95

STARTING LINEUP MLB 2000 ELITE STADIUM STARS KEN GRIFFEY JR REDS OPEN LOOSE VHTF
US $1.95

STARTING LINEUP MLB 1993 STADIUM STARS ROGER CLEMENS RED SOX OPEN LOOSE VHTF
US $1.95

1992 Kenner Starting Lineup SLU Stadium Star Figure Frank Thomas White Sox HOF
US $8.99

1992 Kenner Starting Lineup SLU Stadium Star Figure Ken Griffey Jr Mariners HOF
US $9.99

1992 Kenner Starting Lineup SLU Stadium Star Figure Nolan Ryan No Hit King HOF
US $13.99

1992 Kenner Starting Lineup SLU Stadium Star Figure Roger Clemens Rocket Red Sox
US $13.99

1994 Kenner Starting Lineup SLU Stadium Star Figure Barry Bonds Home Run King
US $17.99

1994 Kenner Starting Lineup SLU Stadium Star Figure Juan Gonzales Texas Rangers
US $7.99

1994 Kenner Starting Lineup SLU Stadium Star Figure Kirby Puckett Twins HOF
US $14.99

1994 Kenner Starting Lineup SLU Stadium Star Figure Reggie Jackson Mr October
US $17.99

1995 Kenner Starting Lineup SLU Stadium Star Figure Frank Thomas White Sox HOF
US $8.99

1995 Kenner Starting Lineup SLU Stadium Star Figure Greg Maddux Braves All Star
US $11.99

STARTING LINEUP MLB 2000 ELITE STADIUM STARS MIKE PIAZZA METS OPEN LOOSE VHTF
US $1.95

Boston Red Sox CARL YASTRZEMSKI Stadium Star Starting Line Up Fenway Park HOF
US $6.99

Texas Rangers IVAN RODRIGUEZ 1998 Stadium Star Starting Line Up Future HOFER
US $4.99

Tampa Bay Rays vs Boston Red Sox Online - Can the Rays Win In Their Home Stadium Today? by Richard Tyler

If you want to know about today's game between the Rays and the Red Sox, we will tell you. Here, we will break down the Red Sox vs the Rays game and let you know who will win.

As a start, let's take a look at the where and the when. The Rays versus Boston MLB game will occur at Tropicana Field on June 15th. If you want to watch this MLB matchup, you can do so easily over the Internet. To view live streams of the content, visit this link:

According to their win-loss record, Boston should take home the victory today. Their record currently stands at 39 - 27 which they'll look to improve today. The Rays will also look to improve their current record of 36 - 31 but they'll have their hands full with Boston in this outing.

We all know in the MLB anything can happen. That is why they play the game after all. Every day is a fresh start.

But now, let's take a look at specifics and see how these teams rank in against others in the MLB.

Watch Rays versus Sox online here.

With their record of 36 - 31, the Rays should not win this game against the Sox. But why not? Well, for one reason, the Tampa Bay Rays will have a tough time stopping Adrian Gonzalez and David Ortiz who lead the Boston Sox in runs batted in this year. You know that Jeremy Hellickson of the Rays will pitch to them very carefully.

But how will today's contest pan out? Will the Tampa Bay Rays be able to take down the Red Sox on their home field? Or, will the road team, the Boston Red Sox, get the win tonight? Great questions but they can only be resolved in the game. If you cannot make it to the game at Tropicana Field or catch it on television, be sure to tune into the Rays-Red Sox game at:

Watch Boston versus Rays online here.

I would like to see this contest at Tropicana Field today but I can't make it. So, to check out David Ortiz, Adrian Gonzalez, Johnny Damon, Matt Joyce and all the other stars, I will watch the Red Sox vs Rays online so I can keep up with my favorite teams and baseball stars.

Keywords: watch MLB online Wednesday, June 15th, watch Tampa Bay Rays vs Boston Red Sox online live, Tropicana Field

About the Author

To read more, swing on by our watch the MLB online website where you can watch MLB games online and get all of the latest MLB statistics.
Star Spangled Banner / National Anthem - Vanderbilt Stadium by 8yo Dominique Baseball 2011

Edition Nib

Fri, 18 May 2012 12:56:49 +0000

Edition Nib

WWE SIN CARA 2 X MASKS GOOD V EVIL ONE OF A KIND MATTEL COSTUME DRESS UP VRARE
US $15.79

Mario Lemieux NHL 1994 Edition Starting Lineup SLU NIP
US $5.00

Boston Celtics Antoine Walker Hotwheels Hot Rod Truck NBA Edition
US $9.99

STARTING LINEUP 1998 EDITION WAYNE GRETZKY FULLY POSEABLE FIGURE DOLL NEW
US $15.00

Derek Jeter UD Playmakers 2002 MLB Edition Bobble Head Figure
US $4.99

WWE SIN CARA COMPLETE MATTEL REPLICA CHILD BOY FANCY DRESS UP COSTUME OUTFIT NEW
US $39.50

BERNIE WILLIAMS LIMITED EDITION 1998 STARTING LINEUP NEW IN BOX FREE SHIPPING
US $8.99

Starting Lineup Derek Jeter 1996 Edition His Rookie Year
US $75.00

NFL Mcfarlane Eli Manning Series 26 White Jersey Variant Limited to 2500 Giants
US $19.99

mcfarlane roger clemons collectors edition No 22 houston astros 2006 NEW MINT
US $5.00

YAO MING McFarlane Action Figure Houston Rockets Series 7 2nd Edition
US $8.99

mcfarlane johan santana series edition 15 minnesota twins 2006 NEW MINT
US $5.00

CHARLES BARKLEY 1997 EDITION FULLY POSEABLE FIGURE NEW IN BOX FREE SHIPPING
US $24.99

mcfarlane scott podsednik series edition 16 chicago white sox 2006 NEW MINT
US $5.00

1998 TIM DUNCAN 12 inch SLU Starting Lineup figure San Antonio Spurs Kenner
US $19.99

mcfarlane vince carter series edition 10 new jersey nets 2005 NEW MINT
US $9.00

FAVRE 1998 LTD ED SIDELINE QUARTERBACKS NFL HEADLINERS new
US $5.99

MUGGSY BOGUES 4 inch figure card 1995 STARTING LINEUP new
US $7.49

DEREK JETER New York Yankees 1998 Kenner Starting Lineup 3 Figure Freeze Frame
US $25.50

1999 KOBE BRYANT Mattel NBA LA Lakers basketball figure w Upper Deck card
US $9.99

mcfarlane vince carter series edition 1 toronto raptors rookie 2002 NEW MINT
US $19.00

1999 TIM DUNCAN Mattel NBA San Antonio Spurs basketball figure w Upper Deck card
US $9.99

mcfarlane carmelo anthony series edition 1 denver nuggets debut 2004 NEW MINT
US $5.00

CLASSIC SUPER STARS LIMITED HULK HOGAN MISB
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mcfarlane lavar arrington series edition 12 washington redskins debut 2005 MINT
US $9.00

mcfarlane corey dillon series edition 12 new england patriots debut 2005 MINT
US $5.00

mcfarlane donovan mcnabb series edition 12 philladelphia eagles debut 2005 MINT
US $5.00

Starting Lineup Sports Superstar Collectibles KEVIN GARNETT 1996 EDITION
US $6.00

STEVE CARLTON 5 Gartlan Limited Edition Figurine w COA 3961 of 10000 pieces
US $14.99

13STARTING LINEUP MEGA LOT COBBWAGNERCY YOUNGJOHNSONMAYS MUST SEE
US $79.00

mcfarlane ladainian tomlinson series edition 12 san diago chargers 2005 MINT
US $5.00

LeBron James 2nd Edition Series 7 Cleveland Cavaliers McFarlane NBA Basketball
US $14.73

Mario Lemieux Team Canada 2004 McFarlane Hockey NHL 6 Stick Puck Display New
US $29.46

WWE Classic Hollywood Blonds Stond Cold Steve Austin Brian Pillman WWF
US $19.99

BARRY BOBBY BONDS 97 EDITION STARTING LINEUP SPORTS SUPERSTAR COLLECTIBLES NIB
US $11.99

GRIFFEY JR SR 1997 EDITION STARTING LINEUP SPORTS SUPERSTAR COLLECTIBLES NIB
US $6.99

AARON ROBINSON 1997 EDITION STARTING LINEUP SPORTS SUPERSTAR COLLECTIBLES NIB
US $4.99

F THOMAS B RUTH 1997 EDITION STARTING LINEUP SPORTS SUPERSTAR COLLECTIBLES NIB
US $4.49

IVAN RODRIGUEZ RANGERS 1998 LIMITED EDITION STARTING LINEUP STADIUM STARS NIB
US $5.29

MIKE PIAZZA DODGERS 1998 LIMITED EDITION STARTING LINEUP STADIUM STARS NIB
US $5.49

MO VAUGHN RED SOX 1998 ED STARTING LINEUP SPORTS SUPERSTAR COLLECTIBLES NIB
US $1.99

ALEX RODRIGUEZ MARINERS 98 ED STARTING LINEUP SPORTS SUPERSTAR COLLECTIBLES NIB
US $3.29

MIKE PIAZZA DODGERS 1998 ED STARTING LINEUP SPORTS SUPERSTAR COLLECTIBLES NIB
US $3.29

GREG MADDOX BRAVES 1998 ED STARTING LINEUP SPORTS SUPERSTAR COLLECTIBLES NIB
US $4.49

Kordell Stewart Starting Lineup 12 action figure1998 mib in original box 10
US $12.00

McFarlane Series 1 Tony Stewart 20 Home Depot Limited Edition Action Figure
US $10.99

WWE Rey Mysterio Tribute to the Troops figure K Mart Exclusive Mattel Jakks WCW
US $9.99

Michael Jordon Mattell Air Maximum NBA Figure MVP Series RARE
US $3.95

NEW Sealed Kenner SLU Classic Goaltenders from 1998 2000 Fuhr Roy Irbe More
US $24.99

Sammy Sosa Mark McGuire Record Breaker Edition PLUS BONUS
US $19.99

Starting Lineup UNOPENEDNEW IN PACKAGE 1990 NFL Edition Randall Cunningham
US $5.99

LEBRON JAMES 23 2nd CLEVELAND CAVALIERS MCFARLANE SPORTS PICKS SERIES 7 2004
US $19.99

3ct DENNIS RODMAN Chicago Bulls HAIR VARIATIONS Red White Yellow
US $14.95

2ct KOBE BRYANT LA Lakers Figures
US $14.95

derek jeter 12 mcfarlane
US $100.00

NEW RIC FLAIR 7 FIGURE WWE FURY UNMATCHED PLATINUM EDITION JAKKS PACIFIC
US $39.99

1999 MARK McGWIRE Minors Majors Starting Lineup SLU
US $4.95

1998 VINCE LOMBARDI HOF Legends Starting Lineup SLU
US $15.98

1998 PEYTON MANNING Rookie Colts Starting Lineup SLU
US $27.95

2000 PEYTON MANNING Vols Colts Classic Double Starting Lineup SLU
US $27.95

Cheap penny auctions by Joesph Legrean

Are you looking for superb deals online? If this is the case you may turn to eBay.com or Craigslist.org. These web sites have great costs on a wide range of new and used items, including pictures, books, cars, clothes, computer games, furniture, home decor, and more. If you aren't an avid Internet user, one of the issues you can run into is Internet acronyms.

You may ask why a Craigslist or eBay seller can't just type out what they need to say. Honestly, it has to do with our modern use of language. This is with the use of abbreviations. Many have grown so used to using them that they don't dare think twice.
Even if you are not a zealous net user, some popular acronyms that sellers use are easy to guess. Sadly, others are much tougher. If you see abbreviations in a Craigslist or eBay listing and you don't know what it implies, contact the vendor for more info. You can also keep on reading on for a catalogue of common abbreviations found on classified web sites and online penny penny auctions websites, as well as their meanings.

DOA means dead on arrival. This phrase is used to describe items that do not work. You are purchasing it and will receive it broken.

Both are used to describe items that are used, but in good condition. In this instance, always ask for photos, as we all have different perspectives on'like new.'
NWT means new with tags. This is most commonly associated with clothes with the tags still attached. Boxed items can be related to NIB, that means new in box. On the other hand, you'll find NWOT or NWOB to describe items that are new without the original tags or boxes.
HTF means difficult to find. LTD means restricted edition. OOP means out of print, which is for books.
You are much more likely to run into acronyms on eBay. now at least you have some idea of what can be expected.

Check out these websites:
Penny auctions - what to look for
Earn big at penny auctions
My boss left me a note or should I say "Odred"?
My boss left me a note or should I say "Odred"?

About the Author

My work as a journalist is still minimal and my focus is on random things. I have went to school at Virginia Tech and am still trying to get back in. You know what they say, once you get out of school and take a break it's really hard to start. .
Thomas and Friends Wooden Railway Collection Part 2

Mlb Action Figure

Fri, 18 May 2012 08:38:59 +0000

Mlb Action Figure

MLB Cooperstown Series 7 Action Figure Thurman Munson
US $11.98

MLB COOPERSTOWN COLLECTION – TOM SEAVER – NIB
US $5.25

Mike Piazza Starting Luneup 2 NY Mets SLU2 Baseball MLB
US $5.00

McFARLANE ROGER CLEMENS 22 Astros 04 HOUSTON ALL STAR GAME Exclusive 6 Figure
US $15.50

McFARLANE MLB Series 6 6 Action Figure Debut LANCE BERKMAN 17 Houston Astros
US $15.50

Mcfarlane MLB 29 Alex Rodriguez July 4th Hat silver variant 145 of 600 MOC
US $36.00

LANCE BERKMAN 17 Houston Astros VARIANT McFARLANE MLBSeries 4 6 Figure Debut
US $27.50

1998 TIM DUNCAN 12 inch SLU Starting Lineup figure San Antonio Spurs Kenner
US $19.99

DEREK JETER New York Yankees 1998 Kenner Starting Lineup 3 Figure Freeze Frame
US $25.50

1999 KOBE BRYANT Mattel NBA LA Lakers basketball figure w Upper Deck card
US $9.99

1999 TIM DUNCAN Mattel NBA San Antonio Spurs basketball figure w Upper Deck card
US $9.99

McFARLANE MLB JOSE REYES 1st Piece 2008 Series 22 MINT WOW
US $2.99

ANDY PETTITTE 21 Houston Astros 2004 McFARLANE Series 10 MLB 6 Action Figure
US $14.50

2004 Mcfarlane MLB Cooperstown 1 NOLAN RYAN Texas Rangers figure MIP HOF
US $12.99

McFARLANE MLB CURT SCHILLING BOSTON RED SOX 22
US $3.99

McFARLANE MLB JORGE POSADA 21 NEW YORK YANKEES Ex Condition
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McFARLANE MLB COOPERSTOWN COLLECTION RYNE SANDBERG Chicago CUBS Series 5
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McFARLANE MLB ICHIRO SUZUKI 51 CF SEATTLE MARINERS SPORTS PICKS MLB SERIES 22
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McFARLANE MLB ALBERT PUJOLS SPORTSPICKS SERIES 19 WITHOUT WS PATCH
US $4.99

McFARLANE MLB NOLAN RYAN CALIFORNIA ANGELS COOPERSTOWN COLLECTION SERIES 3
US $10.00

McFARLANE MLB WILLIE STARGELL PITTSBURGH PIRATES COOPERSTOWN COLLECTION SERIES 2
US $5.99

McFarlane Sports Pick MLB Albert Pujols Series 1 StLouis Cardinals
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McFARLANE MLB HANK AARON COOPERSTOWN COLLECTION SERIES 5
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Jake Peavy Series 16 McFarlane Padres Blue 44 Jersey 2006 Release
US $7.00

McFARLANE MLB TOM SEAVER NY METS COOPERSTOWN COLLECTION SERIES 1
US $5.99

Larry Walker McFarlane Series 4 Figure
US $8.00

Sammy Sosa Big Leagu Challenge Action Figure New in Box See Details Below
US $14.99

Cal Ripken Jr Action Figure by Headliners1998 Brand New in Box
US $.99

NIB Delmon Young Action Figure From 2007
US $.99

Mark McGwire Action Figure 1998
US $.99

NIB Rocco Baldelli Action Figure From 2007
US $.99

Randy Johnson Action Figure NIB With Baseball Card
US $.99

Sammy Sosa Action Figure Baseball Card
US $.99

Sammy Sosa Action Figure
US $.99

2 1989 STARTING LINEUP BASEBALL GREATS MUSIAL GIBSON AND MAYS McCOVEY
US $14.99

McFarlane Toys MLB Baseball 2011 Figure Lot Braves Heyward Phillies Howard NIB
US $29.99

McFarlane MLB 27 Stephen Strasburg All Star 79 100
US $199.99

Mcfarlane MLB 29 Josh Hamilton Texas Rangers Figure NEW Case Fresh
US $17.99

Mcfarlane MLB Series 29 Alex Rodriguez New York Yankees Figure NEW Case Fresh
US $17.99

Chipper Jones 1997 Headliner Atlanta Braves MLB
US $4.99

McFarlane MLB Series 29 Chicago Cubs Starlin Castro CL Bronze Lot of 2 Figures
US $29.99

NY Mets David Wright Action Figure
US $14.99

1998 PREMIER COLLECTION KEN GRIFFEY JR ACTION FIGUURE HEADLINERS UNOPENED
US $7.99

3 Starting Lineup Figures 1993 Gary Sheffield MLBW Roaf 1997NFL Ed Sprague
US $6.00

McFarlane MLB Roberto Clemente PITTSBURGH PIRATES Mint NEW SEALED Cooperstown
US $40.00

2000 Starting Lineup Troy Glaus Collectible Baseball MLB Action Figure and Card
US $9.99

1998 Starting Lineup Derin Erstad Collectible Baseball MLB Action Figure Card
US $9.99

2002 PRO ZONE ALEX RODRIGUEZ NOS NIB TEXAS RANGERS ACTION FIGURE
US $59.95

2008 Daisuke Matsuzaka Boston S21 McFarlane Figure
US $8.95

2008 Carlos Lee Houston Astros Series 22 McFarlane
US $11.95

2009 Mike Lowell Variation Boston RS McFarlane Figure
US $17.50

2011 Chase Utley Philadelphia Phillies McFarlane Figure
US $13.95

2011 Jason Heyward Atlanta Braves S28 McFarlane
US $13.95

2011 Kevin Youkilis Boston Red Sox McFarlane Variant
US $24.95

2011 Kevin Youkilis Boston Red Sox S28 McFarlane
US $13.95

2011 Mariano Rivera New York Yankees S28 McFarlane
US $13.95

2010 Jimmy Rollins Phil Phillies McFarlane
US $13.95

2010 Johan Santana NY Mets McFarlane
US $13.95

Bo Jackson Starting Lineup Sports Super Star Collection Lot Of 6
US $49.00

ALBERT PUJOLS CARDINALS SUPER CHASE YELLOW WRISTBAND MLB SERIES 19 MCFARLANE
US $199.99

Tips For Wagering On Major League Baseball - Part 1 by Nicky Michael

Major League Baseball is somewhat of an enigma. Especially when attempting to use statistics to predict a game's outcome. Even so, there is a lot of data and trends to consider before throwing one's hands up in utter frustration in baseball's defiance of probability. With patience and due diligence, a pattern may emerge. But then a gut feeling comes on and the urge to take the long shot is strong, especially when the pay out is big! The mountain of data, trends and statistics are enough to drive the sanest of us away from the bookmakers, relegating us to the sidelines. However, no one wants to live a life that boring. You can play the game - wager some cash - and make your life a whole lot more exciting.

First off, here are a few ideas to keep your sanity. These are my "top 10 baseball wagering tips for the hopelessly clueless," of which, when it comes to wagering, I am a charter member. If you consider yourself a knowledgeable bettor, these tips will still help you keep your perspective.

1) Don't bet any more than you can afford to lose.
2) Don't ever bet more to recoup a loss.
3) Ignore your gut feelings and/or hunches.
4) If a bet looks too good to be true, it probably is.
5) Once you've made your bet, remember that no amount of stress will change the outcome of a game.
6) Never risk more than 5% of your bankroll on any given game.
7) Don't bet long shots. They are long shots for a reason.
If you are on a losing streak, take a break from wagering.
9) Don't hold grudges over losses- your favorite team won't be much fun to watch if you do.
10) Target long-term goals instead of random or short-term gains.

If you follow these 10 tips then you will be head and shoulders above the average Joe who is placing bets. Of course, you must first understand what you are doing when you wager. Here are some betting basics.

A straight bet is merely betting to win or lose. Sometimes you may not be able to get such a wager without giving or taking points. This is known as the point spread. To win you must "beat the spread", or win by more than a particular team is favored by doing so. This is also known as a form of handicapping. Money lines are pretty simple; it is the amount you need to risk to win $100. So if you see a number in a column marked ML, perhaps -110, you know you need to put up $110 to win $100 and get your $110 back. So if you win, your total payout is $210. The minus sign indicates that team is the favorite. A plus sign in front of the money line indicates the underdog. With over/unders, you are wagering on the total runs that will be scored in the game. You either bet on the number being under or over that total. Action Points refer to that fact that you are betting one team against another. With action points you ignore the starting pitchers, but if there is a change in one or both of the starters, the wager or the payout could be adjusted. Side bets are just what they sound like. You can put side bets on top of your bets. With head to head propositions or match bets you are wagering on one sports figure/team beating another sports figure/team. You can also Buy Points on a handicapped or point spread contest. Usually a straight buy of 1/2 point will cost you $10 on an 11/10 (risk $110 to win $100) standard bet. A straight buy of 1 point would cost $20. If you win, you'll get back what you wagered plus $100. Sports books generally make 10% vigorish, or juice on a typical head to head straight wager. They only make it if you lose your bet.

Sports books will provide information in a compact format. The listing includes the MLB teams and pitchers with the away or visiting team and pitcher listed first and then the home team and pitcher listed underneath. The MLB money line tells you which team is the favorite (- sign) and what you must wager to win a particular amount. The MLB run line is the run differential that the sports book predicts. To win your wager, you have to beat the run line spread. The amount you wager is determined by the money line odds, located right next to the run line spread. Primarily the starting pitchers determine the money line odds. If a run line handicap is +1.5, the bet can still be won if your team loses the game, but only if they lose by one run. If they lose by two runs, you lose your wager. Run lines are always based on the listed pitchers. If the starting pitchers are changed before the game begins, these numbers may also change. The over/under will be a number in the O/U column. If the number were 7, then you would win the wager if the total number of combined runs were 8 or more. A winning under wager would result if 6 runs or less were scored.

All of this may seem rudimentary, but it's the important foundation for MLB betting. Wagering can be as simple or as complicated as you make it. There are some more complex forms of wagering that are beyond the scope of this article. In Major League Baseball Wagering - Part II, we will discuss explanations and strategies of wagering on MLB futures, parlays, multiples, round robins and teasers. We will also discuss the advantages, bonuses, safety and security of choosing a good online sports book site for wagering on MLB.

About the Author

To read about hydrangea care and violet facts, visit the Knowledge Bin website.
MLB action figure collection

Louis Cardinals Starting

Fri, 18 May 2012 07:42:40 +0000

Louis Cardinals Starting

1989 TODD WORRELL Starting Lineup SLU Loose With Card StLouis Cards RARE
US $8.95

1989 PEDRO GUERRERO Starting Lineup SLU Loose With Card StLouis Cards RARE
US $8.95

MARK MCGWIRE CARDINALS 98 ED STARTING LINEUP SPORTS SUPERSTAR COLLECTIBLES NIB
US $6.49

1999 MARK McGWIRE Minors Majors Starting Lineup SLU
US $4.95

1999 MARK McGWIRE Sports Stars Cards Starting Lineup
US $1.95

Vtg TOMMY HERR St Louis Cardinals 1988 STARTING LINEUP Baseball ROOKIE Figure
US $14.99

Vtg TODD WORRELL St Louis Cardinals 1988 STARTING LINEUP Baseball ROOKIE Figure
US $14.99

1998 MARK MCGWIRE Starting Lineup 98 SLU HR HISTORY
US $6.95

1999 MARK MCGWIRE Starting Lineup 99 SLU WALMART HR RB
US $5.95

Starting Lineup Baseball Tom Herr St Louis Cardinals 1988 Kenner
US $10.19

1996 JAY NOVACEK STARTING LINEUP SLU DALLAS COWBOYS NFL ROOKIE FIGURE
US $12.00

1995 DIZZY DEAN STARTING LINEUP SLU COOPERSTOWN COLLECTION FIGURE AND CARD
US $8.55

MARK MCGWIRE As CARDINALS STARTING LINEUP DOUBLE
US $14.95

1999 STARTING LINEUP SPORT STARS MARK MCGWIRE SE
US $19.99

1999 MARK MCGWIRE STARTING LINEUP SLU MLB ST LOUIS CARDINALS FIGURE AND CARD
US $7.55

2000 MARK McGWIRE St Louis Cardinals 500 Home Runs Starting Lineup SLU
US $5.09

Starting Lineup 2000 Comm Mark McGwire Figure Sealed
US $12.95

STARTING LINEUP 1989 ST LOUIS CARDINALS VINCE COLEMAN OPEN LOOSE
US $5.50

1992 FELIX JOSE Starting Lineup SLU Loose With Poster StLouis Cardinals
US $5.25

1990 Pedro Guerrero Starting Lineup SLU Sports Figurine St Louis Cards RARE
US $34.99

1989 Willie McGee Kenner SLU St Louis Cardinals
US $69.99

1988 VINCE COLEMAN St Louis Cardinals Starting Lineup baseball SLU
US $8.49

Drew Bledsoe 1997 Starting Line up Figure Patriots QB
US $5.95

Ozzie Smith New Starting Lineup 1989 St Louis Cardinals Kenner 1988 NIB Figure
US $32.95

Frank Thomas 1994 Starting Line Up Chicago White Sox
US $9.95

Starting Lineup 2000 Edition Mark McGuire Cards
US $3.99

1995 BOB GIBSON Starting Lineup SLU Sports Figurine Loose St Louis Cards
US $6.99

Vintage STARTING LINEUP MLB St Louis Cardinals GREGG JEFFERIES Figure MIP
US $6.99

2000 MARK McGWIRE St Louis Cardinals w Shinguard SLU Starting Lineup
US $5.09

STARTING LINEUP CLASSIC DOUBLES MARK McGWIRE 1999
US $19.99

1989 Terry Pendleton Starting Lineup SLU Sports Figurine StLouis Cardinals
US $89.99

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The Arizona Cardinals Preparing For A Huge Comeback by Abel Lawson

A team in the National Football league that is one of the most watched in the league is the Arizona Cardinals. The team has been making a name for themselves not only in Arizona but in the entire United states as well. The team was started in 1898 making the Cardinals the oldest professional American football club in the United States. The team was originally situated in Chicago. The team moved to St Louis Missouri in 1960 to 1987. The team moved to Arizona in 1988 to prevent the confusion with the baseball team St Louis Cardinals. The supporters of the team continued to show their support despite the many migration the Cardinals made in the past. As the team moved from state to state, they acquired more patrons for the Cardinals Tickets.

The team has won two league championships already. They got these while still playing in Chicago. These games were won before the years of the Super Bowl. However, the team has made 8 appearances in the playoffs already. The Cardinal tickets to such games are easily sold out. Six Division championship titles has also been won by the team.

There is something special associated with the Cardinals tickets.This holds true especially for the home opener games of the team. Due to the arid condition in Arizona, the heat can sometime become too much to handle. This forced the team to play their first few weeks on the road. The earliest time they can play in their home stadium would be on the third week in the season. Most often the home opener of the team would be scheduled on the Sunday night or even the Monday night games.

Since 2006, the team has been playing in the University of Phoenix Stadium. Before the move, the team used to play their games at the Sun Devil stadium of the Arizona State University. The new stadium is able to accommodate more eager fans of the team. The facilities of the stadium are also an improvement on their former home. The location of the University of Phoenix Stadium is also more accessible to the public.

The fans of the Cardinals have been showing their unwavering support for the team. They have noticed and appreciated the improvements the team has been showcasing in the past years. A championship win is near in the horizon for the Arizona Cardinals. And rest assured that as the team wins their first Super Bowl title, the fans would be there to cheer them along the way.

About the Author

Abel Lawson is a freelance writer. He widely writes for sports especially football. He prides himself in finding cheap Cardinal tickets online. He agrees that the best Cardinals tickets are found at http://www.azcardinalstickets.com
St. Louis Cardinals Opening Day Starting Lineup

Bonds Giants

Fri, 18 May 2012 00:14:22 +0000

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FADING GIANTS---The Tendency for Recognized Leaders to "Lose It" as Mega Builders by Eileen Silva

It was a rare moment in networking history: four people with high MLM visibility sat together around one table. One was the man who revolutionized the diet industry, exploding his company to over 300 million within 4 years of its launch and building dozens of million-dollar earners in his 30-year tenure in the MLM industry.

On his left was another legend of MLM--- heir to one of the largest MLM fortunes to ever be amassed and owner of the company that was, arguably, the most charismatic and wealthy meteoric-rise-to-riches ever to hit our industry. My husband, Taylor Hegan, and I, who have made in excess of three million dollars the last few years, as well as creating over a dozen other millionaires in the last decade, rounded out the circle.

When the subject of industry leaders' ability to repeat their successes as they move from one company to another came up, we collectively decided that very few "big" leaders are able to change companies and repeat their track records.

Perhaps the most compelling reason for this is the nature of the dream we sell: "Build an empire that you can manage from the beaches of the world." "Create financial freedom, which gives you the time freedom to spend with your family and your hobbies."

We, who have actively helped mold the industry for the last three decades, have noticed that those who hit the big incomes seldom continue to build and work the business aggressively from a recruitment and growth emphasis after their checks surpass $20,000 a month. In light of that sabotage phenomena, I thought it would be useful to offer up some guidelines to help you avoid becoming a statistic once you hit it big!

I suggest that you: 1. Hire a staff to help you run your business like a business; 2. Never abandon doing the leadership steps that got you there. These include: retailing, advertising, sponsoring, mentoring, training, personal development work, leadership management, daily communication, and event planning. With the current trend in compensation payouts and telecommunication systems, as well as recruiting systems, distributors tend to develop their loyalty to their products and company. One of the biggest money earners of all time recently made this interesting statement: "If I wanted to leave my company today (after more than a decade and $35 million commissions earned), I wouldn't be able to move people with me. They are all so product-bonded that it's not about me, or the lure of an opportunity; it's about the results they are creating through retailing systems and new recruiting systems."

In your less successful days I would encourage you to sponsor your weakness --- in other words--- if you don't like doing mail order, I would encourage you to sponsor someone who did. As you progress up the ladder of success with MLM, let me implore you to hire your weaknesses--- so that within your immediate direction, your office continues to execute all the necessary phases of the business.

Let me also suggest that at the very least you plug back in 10% of your income toward business expenses.... and quite possibly it would be appropriate to invest considerably more than that. Taylor and I spend many thousands per month on expenses, but as he is quick to point out that we have steadily amassed a fortune in the face of this expanded tab.

If you want to avoid becoming a fading giant, you must continuously assess your business developments and surround yourself with a mastermind group that will stimulate you to be the best you can be. Remember: the true great leaders of MLM are not necessarily the biggest earners; they are the most well- rounded performers with industry staying power. Make sure, as you take your career to the superstar level, that you remember the importance of continuing to execute the tasks that originally got you there! You will then be, as multi-millionaire, Charles Givens, has always said, "Ten feet tall and bulletproof."

About the Author

Eileen Silva, Ph.D., N.D. is a metabolic health balancing expert, talk show guest, and lecturer. Dr. Silva is also an individual, group, and corporate weight management consultant. Contact Dr. Silva at http://www.dreileensilva.com
SF Giants: Beyond Barry Bonds

Mets Mcfarlane

Thu, 17 May 2012 17:14:15 +0000

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Paramyotonia congenita by jekky

Symptoms and signs Patients typically complain of muscle stiffness that can continue to focal weakness This muscle stiffness cannot be walked off in contrast to myotonia congenita These symptoms are increased and sometimes induced in cold environments For example some patients have reported that eating ice cream leads to a stiffening of the throat For other patients exercise consistently induces symptoms of myotonia and or weakness Typical presentations of this are during squating or repetitive fist clenching Some patients also indicate that specific foods are able to induce symptoms of paramyotonia congenita Isolated cases have reported that carrots and watermelon are able to induce these symptoms The canonical definition of this disorder precludes permanent weakness in the definition of this disorder In practice however this has not been strictly adhered to in the literature Diagnosis Diagnosis of paramyotonia congenita is made upon evaluation of patient symptoms and case history Myotonia must increase with exercise movement and usually must worsen in cold temperatures Patients that present with permanent weakness are normally not characterized as having PC Electromyography may be used to distinguish between paramyotonia congenita and myotonia congenita Clinicians may also attempt to provoke episodes or myotonia and weakness paralysis in patients in order to determine whether the patient has PC hyperkalemic periodic paralysis or one of the potassium aggravated myotonias Genomic sequencing of the SCN4A gene is the definitive diagnostic determinant Pathophysiology Paramyotonia congenita as well as hyperkalemic periodic paralysis and the potassium aggravated myotonias is caused by mutations in a sodium channel SCN4A The phenotype of patients with these mutations is indicated in Table 1 These mutations affect fast inactivation of the encoded sodium channel There are also indications that some mutations lead to altered activation and deactivation The result of these alterations in channel kinetics is that there is prolonged inward depolarizing current following muscle excitation There is also the introduction of a indow current due to changes in the voltage sensitivity of the channel kinetics These lead to a general increase in cellular excitability as shown in figure 1 Figure 1 Theoretical simulation of a muscle membrane potential in response to 150ms depolarizing pulse of 45pA A Normal muscle produces only a single action potential due to such stimulus This is due to inactivation of sodium channels preventing their further activation even during depolarization B Myotonic muscle however is hyperexcitable and able to produce action potentials for the duration of the stimulus pulse This model adapted from Cannon 1993 There has been one study of a large number of patients with paramyotonia congenita Of 26 kindreds it found that 17 71 had a mutation in SCN4A while 6 29 had no known mutation There is no large difference between these two groups except that patients with no known mutation have attacks precipitated less by cold but more by hunger are much more likely to have normal muscle biopsies and show less decreased compound muscle action potentials when compared to patients with known mutations Table 1 Summary of mutations found in patients diagnosed with paramyotonia congenita and their resulting phenotypes Mutation Region Myotonia Weakness References Cold Exercise Activity Potassium Cold Exercise Activity Potassium R672C D2S4 I693T D2S4 S5 N Y Y Y T704M D2S5 Y Y Y Y S804F D2S6 Y Y Y Y N A1152D D3S4 S5 Y A1156T D3S4 S5 Y Y V1293I D3S4 Y Y N N G1306V D3 4 Y Y Y Y T1313A D3 4 Y Y N Y Y N T1313M D3 4 Y Y N Y Y N M1360V D4S1 Y Y M1370V D4S1 Y Y N N N Y L1433R D4S3 Y Y Y Y N R1448C D4S4 Y Y N N Y N R1448H D4S4 Y Y Y Y Y R1448P D4S4 Y Y Y N R1448S D4S4 Y Y N Y N R1456E D4S4 Y Y N N N N V1458F D4S4 F1473S D4S4 S5 M1592V D4S6 Y Y Y Y Y Y E1702K C term N N F1795I C term Y Symptoms of both PC and hyperKPP Periodica paralytica paramyotonica Also diagnosed as a Potassium aggravated myotonia Original case reports unpublished When exercised in a cold environment After muscles were cooled This table was adapted from Vicart et al 2005 Cold refers to symptoms either occurring or significantly worsening with cold temperatures Likewise Exercise Activity refers to symptom onset or severity worsening with exercise and or more general movement like hand clenching Potassium refers to ingestion of food high in potassium or other disorders which are known to increase serum potassium levels Mutation region nomenclature is domain number e g D1 followed by segment number e g S4 Thus D2S3 indicates that the mutation is in the 3rd membrane spanning loop of the 2nd domain Some mutations occur between segments and are denoted similarly e g D4S4 S5 occurs between the 4th and 5th segments of the 4th domain Other mutations are located between domains and are denoted DX Y where X and Y are domain numbers C term refers to the carboxy terminus Treatment Management Some patients do not require treatment to manage the symptoms of paramyotonia congenita Others however require treatment for their muscle stiffness and often find mexiletine to be helpful Others have found acetazolamide to be helpful as well Avoidance of myotonia triggering events is also an effective method of mytonia prevention Epidemiology Paramyotonia congenita is considered an extremely rare disorder though little epidemiological work has been done Prevalence is generally higher in European derived populations and lower among Asians Epidemiological estimates have been provided for the German population Here it was estimated that the prevalence of PC is between 1 350 000 0 00028 and 1 180 000 0 00056 It should be noted however that the German population of patients with PC is not uniformly distributed across the country Many individuals with PC herald from the Ravensberg area in North West Germany where a founder effect is seems to be responsible for most cases The prevalence here is estimated at 1 6000 or 0 017 History Originally thought to be separate from hyperkalemic periodic paralysis and the sodium channel myotonias there is now considerable disagreement as to whether these disorders represent separate entities or overlapping phenotypes of a complex disorder spectrum External links Paramyotonia congenita FAQ at the Periodic Paralysis News Desk The site also hosts a mailing list for patients with the disorder and medical professionals interested in it Fact page from the Muscular Dystrophy Association Notes Lehmann Horn F Rdel R Ricker K 1993 Non dystrophic myotonias and periodic paralyses A European Neuromuscular Center Workshop held 4 6 October 1992 Ulm Germany Neuromuscul Disord 3 2 1618 doi 10 1016 0960 8966 93 90009 9 PMID 7689382 Cannon S 2006 Pathomechanisms in channelopathies of skeletal muscle and brain Annu Rev Neurosci 29 387415 doi 10 1146 annurev neuro 29 051605 112815 PMID 16776591 References Facts About Myopathies MDA Publications Eulenburg A 1886 ber eine familire durch 6 Generationen verfolgbare Form kongenitaler Paramyotonie Neurol Zentralbl 12 265 72 a b de Silva S Kuncl R Griffin J Cornblath D Chavoustie S 1990 Paramyotonia congenita or hyperkalemic periodic paralysis Clinical and electrophysiological features of each entity in one family Muscle Nerve 13 1 216 doi 10 1002 mus 880130106 PMID 2325698 Subramony S Malhotra C Mishra S 1983 Distinguishing paramyotonia congenita and myotonia congenita by electromyography Muscle Nerve 6 5 3749 doi 10 1002 mus 880060506 PMID 6888415 Streib E 1984 Evoked response testing in myotonic syndromes Muscle Nerve 7 7 5902 PMID 6544373 Cannon S Brown R Corey D 1993 Theoretical reconstruction of myotonia and paralysis caused by incomplete inactivation of sodium channels Biophys J 65 1 27088 doi 10 1016 S0006 3495 93 81045 2 PMID 8396455 a b c Miller T Dias da Silva M Miller H Kwiecinski H Mendell J Tawil R McManis P Griggs R Angelini C Servidei S Petajan J Dalakas M Ranum L Fu Y Ptcek L 2004 Correlating phenotype and genotype in the periodic paralyses Neurology 63 9 164755 PMID 15534250 a b Plassart E Eymard B Maurs L Hauw J Lyon Caen O Fardeau M Fontaine B 1996 Paramyotonia congenita genotype to phenotype correlations in two families and report of a new mutation in the sodium channel gene J Neurol Sci 142 1 2 12633 doi 10 1016 0022 510X 96 00173 6 PMID 8902732 Ptcek L George A Griggs R Tawil R Kallen R Barchi R Robertson M Leppert M 1991 Identification of a mutation in the gene causing hyperkalemic periodic paralysis Cell 67 5 10217 doi 10 1016 0092 8674 91 90374 8 PMID 1659948 Kim J Hahn Y Sohn E Lee Y Yun J Kim J Chung J 2001 Phenotypic variation of a Thr704Met mutation in skeletal sodium channel gene in a family with paralysis periodica paramyotonica J Neurol Neurosurg Psychiatry 70 5 61823 doi 10 1136 jnnp 70 5 618 PMID 11309455 Brancati F Valente E Davies N Sarkozy A Sweeney M LoMonaco M Pizzuti A Hanna M Dallapiccola B 2003 Severe infantile hyperkalaemic periodic paralysis and paramyotonia congenita broadening the clinical spectrum associated with the T704M mutation in SCN4A J Neurol Neurosurg Psychiatry 74 9 133941 doi 10 1136 jnnp 74 9 1339 PMID 12933953 a b c d Ptek L Tawil R Griggs R Meola G McManis P Barohn R Mendell J Harris C Spitzer R Santiago F 1994 Sodium channel mutations in acetazolamide responsive myotonia congenita paramyotonia congenita and hyperkalemic periodic paralysis Neurology 44 8 15003 PMID 8058156 a b McClatchey A McKenna Yasek D Cros D Worthen H Kuncl R DeSilva S Cornblath D Gusella J Brown R 1992 Novel mutations in families with unusual and variable disorders of the skeletal muscle sodium channel Nat Genet 2 2 14852 doi 10 1038 ng1092 148 PMID 1338909 Bouhours M Luce S Sternberg D Willer J Fontaine B Tabti N 2005 A1152D mutation of the Na channel causes paramyotonia congenita and emphasizes the role of DIII S4 S5 linker in fast inactivation J Physiol 565 Pt 2 41527 doi 10 1113 jphysiol 2004 081018 PMID 15790667 a b McClatchey A Van den Bergh P Pericak Vance M Raskind W Verellen C McKenna Yasek D Rao K Haines J Bird T Brown R 1992 Temperature sensitive mutations in the III IV cytoplasmic loop region of the skeletal muscle sodium channel gene in paramyotonia congenita Cell 68 4 76974 doi 10 1016 0092 8674 92 90151 2 PMID 1310898 Lerche H Heine R Pika U George A Mitrovic N Browatzki M Weiss T Rivet Bastide M Franke C Lomonaco M Human sodium channel myotonia slowed channel inactivation due to substitutions for a glycine within the III IV linker J Physiol 470 1322 PMID 8308722 Bouhours M Sternberg D Davoine C Ferrer X Willer J Fontaine B Tabti N 2004 Functional characterization and cold sensitivity of T1313A a new mutation of the skeletal muscle sodium channel causing paramyotonia congenita in humans J Physiol 554 Pt 3 63547 doi 10 1113 jphysiol 2003 053082 PMID 14617673 a b c d Ptacek L Gouw L Kwieciski H McManis P Mendell J Barohn R George A Barchi R 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